tests/dev/Qualification-Minimal/reporting engine input/Inputs/Midazolam/Compound/Midazolam.md

In Open-Systems-Pharmacology/OSPSuite.ReportingEngine: R package to create reports for the Open Systems Pharmacology models

Compound: Midazolam

Parameters

Name | Value | Value Origin | Alternative | Default ------------------------------------------------ | -------------- | ------------------------------------------------- | ------------ | ------- Solubility at reference pH | 0.049 mg/ml | Publication-FaSSIF (Heikkinen 2012) | Measurement | True Reference pH | 6.5 | Publication-FaSSIF (Heikkinen 2012) | Measurement | True Lipophilicity | 3.13 Log Units | Database-Unknown-Drugbank | Measurement | True Fraction unbound (plasma, reference value) | 0.2 | Parameter Identification-Parameter Identification | Measurement | True Specific intestinal permeability (transcellular) | 2E-06 dm/min | Parameter Identification-Parameter Identification | Optimization | True Cl | 1 | | | F | 1 | | | Is small molecule | Yes | | | Molecular weight | 325.77 g/mol | | | Plasma protein binding partner | Albumin | | |

Calculation methods

Name | Value ----------------------- | ------------------- Partition coefficients | Rodgers and Rowland Cellular permeabilities | PK-Sim Standard

Processes

Metabolizing Enzyme: CYP3A4-Optimization

Molecule: CYP3A4

Parameters

Name | Value | Value Origin -------------------- | ------------ | ------------------------------------------------- Enzyme concentration | 1 µmol/l | Vmax | 0 µmol/l/min | Km | 2.73 µmol/l | kcat | 13 1/min | Parameter Identification-Parameter Identification

Systemic Process: Glomerular Filtration-GFR

Species: Human

Parameters

Name | Value | Value Origin ------------ | -----:| ------------: GFR fraction | 1 |

Open-Systems-Pharmacology/OSPSuite.ReportingEngine documentation built on May 1, 2024, 12:27 p.m.